نتایج جستجو برای: In silico studies

تعداد نتایج: 17135010  

Journal: :iranian journal of basic medical sciences 0
azizeh asadzadeh department of biology, science and research branch, islamic azad university, tehran, iran hajar sirous department of medicinal chemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran morteza pourfarzam department of medicinal chemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran parichehreh yaghmaei department of biology, science and research branch, islamic azad university, tehran, iran afshin fassihi department of biochemistry, school of pharmacy and pharmaceutical sciences, isfahan university of medical sciences, isfahan, iran

objective(s): tyrosinase is a key enzyme in pigment synthesis. overproduction of melanin in parts of the skin results in hyperpigmentation diseases. this enzyme is also responsible for the enzymatic browning in fruits and vegetables. thus, its inhibitors are of great importance in the medical, cosmetic and agricultural fields. materials and methods: a series of twelve kojic acid derivatives wer...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهید مدنی آذربایجان - دانشکده زبانهای خارجی 1391

since esp received universal attention to smooth the path for academic studies and productions, a great deal of research and studies have been directed towards this area. swales’ (1990) model of ra introduction move analysis has served a pioneering role of guiding many relevant studies and has proven to be productive in terms of helpful guidelines that are the outcome of voluminous productions ...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده زبانهای خارجی 1389

this study investigates the strategies native english and persian speakers employ for expressing gratitude in different situations. the strategies of persian efl learners are also compared with english strategies in order to find the differences that may exist between these two languages. social status and size of imposition of the favor are social variables which are investigated in detail for...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه اصفهان - دانشکده زبانهای خارجی 1392

abstract this study investigated the predictability of variables from a motivational framework as well as individuals qualities to predict three non-linguistic outcomes of language learning. gardners socio-educational model with its measures has been used in the current study. individual qualities presented in this study include (1) age, (2) gender, and (3) language learning experience. the...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه فردوسی مشهد - دانشکده ادبیات و علوم انسانی دکتر علی شریعتی 1392

a large number of single research studies on the effects of strategy-based instruction (sbi) in teaching english as a foreign or second language has been conducted so far. however, the lack of a comprehensive meta-analysis targeting the effectiveness of english language sbi is observed. moreover, the findings of experimental studies regarding the context of the english language, proficiency lev...

Journal: :jundishapur journal of microbiology 0
somayeh shatizadeh malekshahi virology department, school of public health, tehran university of medical sciences, tehran, ir iran ehsan arefian department of microbiology, school of biology, college of science, university of tehran, tehran, ir iran vahid salimi virology department, school of public health, tehran university of medical sciences, tehran, ir iran talat mokhtari azad virology department, school of public health, tehran university of medical sciences, tehran, ir iran jila yavarian virology department, school of public health, tehran university of medical sciences, tehran, ir iran; virology department, school of public health, tehran university of medical sciences, tehran, ir iran. tel/fax: +98-2188962343

results in this study, seven sirna molecules were rationally designed against the nucleoprotein gene and validated using various computational methods for silencing different strains of rsv. additionally, three effective sirna molecules targeting the overlapping region of m2/l mrna were designed. conclusions this approach provides insight and a validated strategy for chemical synthesis of an an...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه مازندران - پژوهشکده علوم انسانی و اجتماعی 1391

the central purpose of this study was to conduct a case study about the role of self monitoring in teacher’s use of motivational strategies. furthermore it focused on how these strategies affected students’ motivational behavior. although many studies have been done to investigate teachers’ motivational strategies use (cheng & d?rnyei, 2007; d?rnyei & csizer, 1998; green, 2001, guilloteaux & d?...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه کاشان - دانشکده ادبیات و زبانهای خارجی 1394

cohesion is an indispensable linguistic feature in discourse analysis. lexicald such a differe cohesion and conjunction in particular as two crucial elements to textual cohesion and comprehension has been the focus of a wide range of studies up to now. yet the relationship between the open register and cohesive devices has not been thoroughly investigated in discourse studies. this study concen...

پایان نامه :دانشگاه آزاد اسلامی - دانشگاه آزاد اسلامی واحد شاهرود - دانشکده علوم انسانی 1393

recent studies in scientific education as well as foreign and second language instruction suggest that thinking has rarely been an integral part of education and training in classroom. some scholars decried the lack of emphasis on thinking in the institutes and schools. they noted that memorization and drills were rewarded,while inquiry, reflection, and consideration of alternatives were frowne...

Journal: :iranian journal of pharmaceutical research 0
kamaleddin haj mohammad ebrahim tehrani department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. farzad kobarfard 1- department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- phytochemistry research center, shahid beheshti university of medical sciences, tehran, iran. parisa azerang drug design and bioinformatics unit, medical biotechnology department, biotechnology research center, tehran, pasteur institute, 13164, iran. maryam mehravar drug design and bioinformatics unit, medical biotechnology department, biotechnology research center, tehran, pasteur institute, 13164, iran. zohreh soleimani department of medicinal chemistry, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. ghazaleh ghavami drug design and bioinformatics unit, medical biotechnology department, biotechnology research center, tehran, pasteur institute, 13164

in this work, we reported the synthesis and evaluation of antimycobacterial and antifungalactivity of a series of thiocarbohydrazone derivatives which are thiacetazone congeners. thetarget compounds were synthesized in superior yields by reacting thiocarbohydrazide withdifferent aromatic aldehydes and methyl ketones. compounds 8, 19 and 25 were found to bethe most potent derivatives, exhibiting...

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